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Douglas Hanahan Selected Research

ErbB Receptors (EGF Receptor)

10/2010Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis.
2/2010Differential contribution to neuroendocrine tumorigenesis of parallel egfr signaling in cancer cells and pericytes.

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Douglas Hanahan Research Topics

Disease

73Neoplasms (Cancer)
01/2022 - 03/2002
31Carcinogenesis
11/2019 - 03/2002
10Neoplasm Metastasis (Metastasis)
11/2019 - 04/2006
8Neuroendocrine Tumors (Neuroendocrine Tumor)
11/2019 - 02/2010
8Carcinoma (Carcinomatosis)
11/2018 - 05/2002
8Primitive Neuroectodermal Tumors (PNET)
01/2015 - 08/2010
5Breast Neoplasms (Breast Cancer)
01/2019 - 05/2002
5Adenocarcinoma
01/2016 - 04/2006
4Melanoma (Melanoma, Malignant)
10/2018 - 06/2003
4Pancreatic Neoplasms (Pancreatic Cancer)
03/2016 - 05/2002
3Uterine Cervical Neoplasms (Cancer of the Cervix)
06/2010 - 09/2004
2Glioblastoma (Glioblastoma Multiforme)
12/2017 - 03/2009
2Inflammation (Inflammations)
09/2017 - 02/2010
2Colorectal Neoplasms (Colorectal Cancer)
11/2015 - 05/2013
2Hypoxia (Hypoxemia)
08/2011 - 10/2005
2Lymphatic Metastasis
10/2007 - 05/2002
2Insulinoma
11/2003 - 09/2003
1Brain Neoplasms (Brain Tumor)
12/2017
1Disease Progression
01/2016
1Microsatellite Instability
11/2015
1Glioma (Gliomas)
10/2015

Drug/Important Bio-Agent (IBA)

11Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2017 - 03/2002
9Proteins (Proteins, Gene)FDA Link
01/2018 - 05/2004
7Peptides (Polypeptides)IBA
11/2018 - 11/2003
6LigandsIBA
11/2019 - 03/2002
6Angiogenesis InhibitorsIBA
10/2016 - 08/2008
6CathepsinsIBA
01/2016 - 05/2004
6Pharmaceutical PreparationsIBA
11/2015 - 05/2002
5VaccinesIBA
01/2020 - 06/2003
5AntigensIBA
11/2018 - 06/2003
5Messenger RNA (mRNA)IBA
12/2015 - 06/2005
5Cysteine (L-Cysteine)FDA Link
01/2015 - 05/2004
5Cadherins (E-Cadherin)IBA
09/2010 - 05/2002
4Peptide Hydrolases (Proteases)FDA Link
01/2016 - 05/2004
4DNA (Deoxyribonucleic Acid)IBA
01/2013 - 06/2003
4Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
12/2011 - 02/2005
4Imatinib Mesylate (Gleevec)FDA Link
06/2011 - 05/2003
4Phosphotransferases (Kinase)IBA
10/2010 - 05/2003
3Biological ProductsIBA
01/2020 - 04/2006
3Oncogene Proteins (Oncogene Protein)IBA
01/2020 - 10/2005
3MicroRNAs (MicroRNA)IBA
11/2019 - 09/2009
3AntibodiesIBA
12/2017 - 06/2003
3Biomarkers (Surrogate Marker)IBA
09/2017 - 10/2010
3Cysteine Proteases (Cysteine Protease)IBA
01/2015 - 05/2004
3EnzymesIBA
11/2013 - 10/2004
2Neoplasm Antigens (Tumor Antigens)IBA
01/2020 - 05/2002
2activin BIBA
11/2019 - 01/2019
2Glutamic Acid (Glutamate)FDA Link
01/2019 - 03/2013
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
01/2018 - 03/2013
2Glucose (Dextrose)FDA LinkGeneric
10/2016 - 11/2013
2Cathepsin EIBA
01/2016 - 07/2013
2CopperIBA
11/2013 - 06/2010
2Sunitinib (Sutent)FDA Link
12/2011 - 02/2005
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/2011 - 08/2007
2ErbB Receptors (EGF Receptor)IBA
10/2010 - 02/2010
2Tumor Viral Antigens (Large T Antigen)IBA
08/2010 - 10/2005
2Insulin-Like Growth Factor II (Somatomedin A)IBA
06/2010 - 05/2002
2Transforming Growth Factor beta (TGF-beta)IBA
01/2009 - 11/2006
2Metalloproteases (Metalloproteinases)IBA
04/2008 - 08/2006
2Matrix Metalloproteinases (MMPs)IBA
04/2008 - 06/2003
2Matrix Metalloproteinase 9 (Gelatinase B)IBA
04/2008 - 04/2003
2Heat-Shock Proteins (Heat-Shock Protein)IBA
03/2005 - 06/2003
2Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
02/2005 - 05/2002
2Insulin (Novolin)FDA Link
04/2004 - 09/2003
2Explosive Agents (Explosives)IBA
03/2004 - 05/2002
1Phenobarbital (Luminal)FDA Link
01/2019
1Paclitaxel (Taxol)FDA LinkGeneric
01/2019
1Carboplatin (JM8)FDA LinkGeneric
01/2019
1InterferonsIBA
12/2017
1Programmed Cell Death 1 ReceptorIBA
12/2017
1Vascular Endothelial Growth Factor CIBA
09/2017
1Glutamine (L-Glutamine)FDA Link
10/2016
1Lactic Acid (Lactate)FDA LinkGeneric
10/2016
1Monocarboxylic Acid TransportersIBA
10/2016
1Agammaglobulinaemia Tyrosine KinaseIBA
03/2016
1ibrutinibIBA
03/2016
1Ritonavir (Norvir)FDA Link
01/2016
1procathepsin EIBA
01/2016
1Aspartic Acid ProteasesIBA
01/2016
1Transforming Growth Factors (Transforming Growth Factor)IBA
11/2015
1Ticlopidine (Ticlid)FDA LinkGeneric
10/2015
1Imipramine (Janimine)FDA LinkGeneric
10/2015
1Purinergic P2Y12 ReceptorsIBA
10/2015
1AnticoagulantsIBA
10/2015
1Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA
10/2015
1Cathepsin LIBA
01/2015
1Trace Elements (Biometals)IBA
11/2013
1Electron Transport Complex IV (Cytochrome c Oxidase)IBA
11/2013
1CarcinogensIBA
11/2013
1Drinking WaterIBA
11/2013
1Adenosine Triphosphate (ATP)IBA
11/2013
1SphingomyelinsIBA
09/2013
1Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
09/2013
1AcidsIBA
09/2013
1Lu 28-179 (Siramesine)IBA
09/2013

Therapy/Procedure

25Therapeutics
01/2022 - 05/2002
5Immunotherapy
01/2020 - 05/2002
5Drug Therapy (Chemotherapy)
01/2019 - 02/2005
1Precision Medicine
01/2020
1Chemoradiotherapy
07/2013